Research progress on the molecular mechanisms of hepatic metastasis in lung cancer: a narrative review

: The liver is one of the most common sites metastatic spread lung cancer, and process metastasis regulated by many factors. A number genes, including multiple tumor suppressor 1 (mts1), p120 catenin, CT45A1, increase possibility hepatic in whereas Tip30/CC3, CUL5, SOCS3 expression tumors inhibit metastasis. microRNAs (miRNAs), such as miRNA-126, miRNA-338, miRNA-218, can affect cancer cells to liver. D114-Notch signaling pathway small cell cancer. Serum markers cytokeratin 19 fragment antigen 21-1 neuron-specific enolase (NSE) are closely related risk Based on previously published literature, we found that invasion determined molecular Therefore, selective identification intervention these erroneous signals predict early In this review article, describe mechanisms influencing factors (genes, signal pathways, chemicals, proteins, miRNAs) We hope provide a summary evidence for which genes or proteins malignancy from so doctors researchers improve treatment options.